2016 Fiscal Year Final Research Report
Molecular bases for intracellular trafficking and functional signalosome formation mediated through histamine H3 receptor
| Project/Area Number |
26460331
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Tohoku University |
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Principal Investigator |
Sukegawa Jun 東北大学, 医学系研究科, 非常勤講師 (30187687)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | Gタンパク質共役型受容体 / ヒスタミンH3受容体 / カルボキシル末端 / シグナロソーム / 膜輸送 / ユビキチン化 |
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| Outline of Final Research Achievements |
Through direct interactions with G protein-coupled receptors, various proteins regulate cellular distribution and signal transduction of the receptors. The protein complex is so called “signalosome”. In the present study, we investigated roles of DRiP78 and Rab8, as examples of signalosome molecules, in functions of histamine H3 receptor with the central focus on the receptor’s cellular distribution. We found that DRiP78 and Rab8 are involved in reduction and increase in plasma membrane distribution of the receptor, respectively.
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| Free Research Field |
分子細胞生物学
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