2016 Fiscal Year Final Research Report
New therapeutic strategy for brain-cardiorenal-glucose metabolism syndrome: targeting on the sympathetic nervous system and SGLT2
| Project/Area Number |
26460343
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 生活習慣病 / 肥満 / 糖尿病 / 腎臓病 / レニンアンジオテンシン系 / SGLT2 / インスリン抵抗性 / 血圧 |
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| Outline of Final Research Achievements |
We aimed to determine the potential roles of sympathetic nervous system, renin-angiotensin system and SGLT2 in the pathophysiology of brain-cardiorenal-glucose metabolism syndrome during the development of obese and diabetes. Our data have shown that during the development of obese and diabetes, 1) the brain-cardiorenal-glucose metabolism syndrome is exists, 2) sympathetic nervous system and intrarenal renin-angiotensin system and SGLT2 play an important role in the pathogenesis of brain-cardiorenal-glucose metabolism syndrome, 3) brain-cardiorenal-glucose metabolism syndrome contributes to the progression of diabetes cardiovascular and renal complications. These data may help to develop new strategy for diabetes cardiovascular and renal complications.
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| Free Research Field |
薬理学
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