2016 Fiscal Year Final Research Report
The role of exosome on the onset and development of arteriosclerosis
| Project/Area Number |
26460344
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Osaka City University |
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Principal Investigator |
Izumi Yasukatsu 大阪市立大学, 大学院医学研究科, 非常勤講師 (10347495)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIOTA Masayuki 大阪市立大学, 大学院医学研究科, 講師 (30381990)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | エキソソーム / 動脈硬化 / 内皮障害 |
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| Outline of Final Research Achievements |
Metabolic syndrome (MetS) induces serious complications. We succeeded a noninvasive MetS model using an extremely small minipig. The protein level of serum exosomes in this model was increased, compared with that in normal diet group. Unfortunately, we viewed harshly the continuation of the analysis in this model. Therefore, we performed the analysis using a mouse model.
The deficient mice with neither endothelial nitric oxide synthase nor apolipoprotein E were used. The mice acutually expressed both hypertension and dyslipidemia by normal diet. We established the extraction and purification method from mouse serum exosomes.
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| Free Research Field |
循環薬理学
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