Mechanisms of insulin treatment-induced hypertension in diabetes mellitus

2018 Fiscal Year Final Research Report

• Project/Area Number: 26460346
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General pharmacology
• Research Institution: Showa University (2015-2018); Josai University (2014)
• Principal Investigator: Nobe Koji 昭和大学, 薬学部, 教授 (30276612)
• Co-Investigator(Kenkyū-buntansha): 竹之内 康広 川崎医科大学, 医学部, 助教 (30582233) ; 加園 恵三 城西大学, 薬学部, 教授 (90177387)
• Project Period (FY): 2014-04-01 – 2019-03-31
• Keywords: 糖尿病 / 高血圧症 / インスリン / 血管平滑筋 / 血管内皮細胞 / rho A

Outline of Final Research Achievements

Insulin is widely used for a control of blood glucose level in diabetic patients. It is pointed out that a possibility of the insulin-treatment enhances blood pressure in diabetes, however, details of the mechanisms have not been understood. In this study, we confirmed the insulin-dependent enhances of blood pressure in streptozocin-induced diabetic mouse. This secondary-hypertension was detected only in diabetic mouse, time- and dose-dependent manners. As the mechanism of the enchancement, we revealed that the rho A mediated pathway is involved in the hypertension without mediating by dysfunctions of vascular endothelial cells and NO-mediated pathway. These findings suggests that the insulin influences an intercellular signaling pathway in vascular smooth muscle cells.

Free Research Field

薬理学

Academic Significance and Societal Importance of the Research Achievements

本研究は、糖尿病治療で汎用されているインスリン治療が、患者の血圧を上昇させる可能性について着目しており、そのメカニズムを解明することにより、インスリン導入時の血圧上昇リスクを軽減することに貢献すると考えられる。特に糖尿病患者には高血圧症を併発している場合が多く、今後の高齢化社会においてその学術的価値は高まると予想される。