2016 Fiscal Year Final Research Report
Elucidation of environmental factors involved in the onset of hyperuricemia using complete model animals of human uric acid metabolism
| Project/Area Number |
26460347
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Teikyo University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 尿酸 |
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| Outline of Final Research Achievements |
1. Successful breeding of B6/XcMSM mice reported to have a higher HPRT activity than experimental mice such as C57BL/6 and successive breeding exceeding reproductive septa associated with subspecies differences. 2. We confirmed that B6/XcMSM mice have HPRT high activity allele and established genotyping method of HPRT allele. 3. By using B6/XcMSM mouse, suppression of hypoxanthine release by blood purinergic system with HPRT high activity was observed in blood cells without Xanthine oxidoreductase (Xor) activity. 4. UoxKO-XcMSM mouse creation enabled us to obtain mice that were close to human uric acid metabolism except that Xor was highly active.
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| Free Research Field |
核酸代謝
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