2016 Fiscal Year Final Research Report
Mechanisms of heat hyper- and hypoalgesia by peripheral metabotropic glutamate receptors
| Project/Area Number |
26460348
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
NISHIO Matomo 金沢医科大学, 医学部, 教授 (80156041)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 代謝型グルタミン酸受容体 / 後根神経節 / 痛覚過敏 / TRPV1 |
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| Outline of Final Research Achievements |
Wounds and inflammation cause glutamate release from primary sensory nerve afferents and damaged cells in the peripheral tissue. In this study, we have revealed that glutamate acts on metabotropic glutamate receptors 1 and 5 (mGluR1/5) in dorsal root ganglion neurons, resulting in potentiation of TRPV1 activities, inhibition of voltage-gated calcium channels and increase of neurons expressing functional TRPV1. These effects are closely associated to multiphasic modulation by glutamate of pain.
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| Free Research Field |
薬理学
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