2016 Fiscal Year Final Research Report
Research for heart protection during cancer chemotherapy via regulating cardiac autophagy
Project/Area Number |
26460350
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General pharmacology
|
Research Institution | Tenri Health Care University |
Principal Investigator |
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Keywords | 心不全 / 抗がん剤 / ミトコンドリア / オートファジー / エネルギー代謝 |
Outline of Final Research Achievements |
Using GFP-LC3 transgenic mice or neonatal rat cardiac myocytes, we demonstrated that Curcumine inhibited both cardiac apoptosis and cardiac dysfunction induced-by Doxorubicin. Curcumine significantly improved mortality in mice with anti-cancer chemotherapy (Clin Exp Card.2015). Also, we showed that cardiac autophagy was activated and acted as cardioprotection by through mTOR-independent Akt signal in the heart failure with sympathicotonia (Biochem Biophys Res Commun.2014). In addition, defect in metabolism of lipid and amino acid was revealed to be a key for the progress of heart failure (Am J Physiol Heart Circ Physio.2016, Sci Rep 2017). These findings indicated that regulating energy metabolism and autophagy would be a novel therapeutic target for heart failure with cancer chemotherapy.
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Free Research Field |
循環器内科学
|