2016 Fiscal Year Final Research Report
Analysis of tumor suppressors RASSF3 and RASSF6
| Project/Area Number |
26460359
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
Iwasa Hiroaki 東京医科歯科大学, 大学院医歯学総合研究科, 助教 (70582188)
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| Co-Investigator(Renkei-kenkyūsha) |
Maruyama Junichi 東京医科歯科大学, 大学院医歯学総合研究科, 助教 (30723639)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | シグナル伝達 / 腫瘍抑制 / フェイルセーフ / RASSF |
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| Outline of Final Research Achievements |
Ras association domain family (RASSF) cooperates with tumor suppressors. The RASSF tumor suppressor genes are frequently inactivated in many types of human cancer. In this study we found that a novel tumor suppressor acts through RASSF. We also found that a cellular precursor state of tumor changes the structure of RASS protein to suppress tumor formation. Thus we propose that RASSF is a primary fail-safe mechanism of oncogene-driven tumorigenesis.
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| Free Research Field |
分子生物学
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