2016 Fiscal Year Final Research Report
Regulation and biological significance of mitochondrial c-Src.
| Project/Area Number |
26460372
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
Homma Yoshimi 福島県立医科大学, 医学部, 教授 (60192324)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | ミトコンドリア / 活性酸素 / チロシンキナーゼ |
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| Outline of Final Research Achievements |
Suppression of c-Src activity enhances production of radical oxygen species (ROS) in mitochondria. We identified flotillin-1 as a c-Src substrate that prevent ROS production. We produced transgenic (Tg) mice expressing a phosphorylation-defective mutant of succinate dehydrogenase A in B cells. Splenic B cells in male, but not female, Tg mice produced enhanced ROS, and exhibited decreased humoral immune response.
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| Free Research Field |
シグナル伝達
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