2016 Fiscal Year Final Research Report
Roles of the histone variant H3.3 on the distal enhancer of differentiation specific gene.
| Project/Area Number |
26460373
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
General medical chemistry
|
|---|
| Research Institution | Yokohama City University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
TAMURA Tomohiko 横浜市立大学, 医学研究科, 教授 (50285144)
KUROTAKI Daisuke 横浜市立大学, 医学部, 講師 (10568455)
|
|---|
| Research Collaborator |
FUSHIMI Kentaro
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 細胞分化 / エピジェネティックス / 遺伝子発現 |
|---|
| Outline of Final Research Achievements |
Gene expression during cell differentiation is regulated by the epigenetic mechanisms, including histone variants, as well as lineage specific transcription factors. Histone variant H3.3 is known to be deposited in transcribed genes and associated with possibly maintenance of transcriptional memory. However, the functions of H3.3 on the distal enhancer are still unclear. In this study, we analyzed the roles of H3.3 on the distal enhancer of differentiation specific gene. H3.3 was first molecule that was deposited on both the distal enhancer and the proximal promoter synchronously, suggesting that H3.3 promotes the cooperation between the distal enhancer and the proximal promoter.
|
| Free Research Field |
分子生物学
|
