2016 Fiscal Year Final Research Report
Investigation of neural circuits responsible for behavioral abnormalities caused by Dgcr8 deficiency
Project/Area Number |
26460381
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General medical chemistry
|
Research Institution | Research Institute, Shiga Medical Center |
Principal Investigator |
Muraki Kazue 滋賀県立成人病センター(研究所), 神経病態研究部門, 主査 (10725857)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Keywords | Dgcr8 / 22q11 deletion syndrome / schizophrenia / Cre / BAC / hippocampus / interneuron / dentate gyrus |
Outline of Final Research Achievements |
22q11 deletion syndrome is a chromosome disorder. 20-30% of the patients with this deletion develop schizophrenia. We demonstrated the heterozygous deletion of Dgcr8 caused developmental abnormalities in the dentate gyrus of the hippocampus and cortical interneruons. To perform rescue experiments by Dgcr8 overexpression, we newly generated ROSA-CAG-stop-Dgcr8 BAC transgenic mice, which express Dgcr8 specifically in Cre-expressing cells.
|
Free Research Field |
神経発生学
|