2016 Fiscal Year Final Research Report
Hepatic tumor and Nrf2 activation by impaired autophagy
Project/Area Number |
26460384
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pathological medical chemistry
|
Research Institution | Tohoku University |
Principal Investigator |
Taguchi Keiko 東北大学, 医学系研究科, 助教 (20466527)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Keywords | Nrf2 / オートファジー / 肝腫瘍 |
Outline of Final Research Achievements |
Autophagy is a mechanism to maintain protein quality in cells. impaired autophagy leads to Nrf2 activation through aberrant accumulation of p62 protein. Autophagy-impaired mice develop hepatic tumors. In this study, Nrf2 activation contributes to tumor formations.
|
Free Research Field |
生化学
|