2016 Fiscal Year Final Research Report
Novel molecular mechanisms that regulate tumor invasion and metastasis by association of cancer cells with surrounding stroma cells
| Project/Area Number |
26460389
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 細胞接着 / シグナル伝達 |
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| Outline of Final Research Achievements |
I focused on the tumor invasion and metastasis that is a major course of cancer death, and constructed the model to reflect this pathological condition in vitro. Using this model, I conducted the genome-wide analysis by DNA microarray assay to identify the genes of which expression was significantly increased in target cancer cells. After this analysis, I could select one gene. The gene product (molecule) is reported to localize on the plasma membrane of cancer cells. I found that the molecule remarkably promoted cancer cell motility, and that tumor invasion and metastasis was highly observed in the mice in which the cancer cells overexpressing the molecule were implanted. Furthermore, the signal transduction mechanism to facilitate cancer cell motility by this molecule was revealed successfully.
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| Free Research Field |
生化学
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