The new function of insulin in gut.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460392
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pathological medical chemistry
• Research Institution: Kumamoto University
• Principal Investigator: Yoshizawa Tatsuya 熊本大学, 大学院生命科学研究部(医), 准教授 (40313530)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: インスリン / 糖代謝 / 腸管

Outline of Final Research Achievements

Gut is the tissue that is important to glucose metabolism, but it is not clear about the insulin action to gut. Therefore applicants generated the gut-specific insulin acceptor knockout (IR gutCKO) mice and analyzed influence on glucose metabolism. The IR gutCKO mice showed impaired glucose tolerance in the glucose tolerance test. In addition, expressions of many genes concerned with immunoreaction were changed in the gut of the IR gutCKO mice, and intestinal flora was changed in the IR gutCKO mice. These results indicate that an enteric insulin signal modulate immune system and change intestinal flora, thereby controlling glucose metabolism. Furthermore, it was shown that gut was the organ, which is hard to cause high fat diet-induced insulin resistance.

Free Research Field

基礎医学