2016 Fiscal Year Final Research Report
Relationships between the regulation mechanisms of sex differentiation and the epigenetic status in the developing gonad
| Project/Area Number |
26460410
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human genetics
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| Research Institution | Kobe University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 性分化 / 性分化疾患 / エピジェネティクス / SRY / DMRT1 |
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| Outline of Final Research Achievements |
We examined the relationship between regulation mechanisms of gonadal sex differentiation and disorders of sex development (DSD). In the DSD line mice (YPOS), inappropriate spatiotemporal expression of sex determine gene Sry and sex differentiation related genes in the developing gonad cause different phenotype from the same genetic background. We found new regulatory mechanism about sex differentiation related gene dmrt1 using non-coding region of dmrt1 gene. The epigenetic status of this region was non-methylated both in the testis and ovary in adult mice. Furthermore, it became clear that, there were asymmetries in the expression patterns of dmrt1 and differentiation process of Sertoli cells in the developing chick gonad.
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| Free Research Field |
人類遺伝学
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