2016 Fiscal Year Final Research Report
Significance of DNA damage response in histogenesis of colorectal carcinoma
Project/Area Number |
26460415
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Human pathology
|
Research Institution | Niigata University |
Principal Investigator |
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Keywords | 大腸癌の発生 / 腺腫の癌化 / 鋸歯状病変 / 炎症性発癌 / DNA二重鎖切断 / DNA損傷修復応答 |
Outline of Final Research Achievements |
Colorectal carcinogenesis occurs through various pathways; ①de novo cancerization (carcinogenesis in normal mucosa), ②adenoma-carcinoma sequence, ③cancerization from hyperplastic polyp or SSA/P, ④inflammatory carcinogenesis occurs in inflammatory mucosa such as ulcerative colitis. This study investigated whether or not DNA damage and DNA damage response play a role in these carcinogenetic pathways. As the result, it was speculated that accumulation of DNA damage play a role in cancerization in non-neoplastic inflammatory mucosa in pathway-④, and in precancerous lesions in pathway-②③. DNA damage response failure may play a role in development of invasive carcinoma.
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Free Research Field |
人体病理学
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