2017 Fiscal Year Final Research Report
Significance of glycosylation of alpha-dystroglycan in perineural invasion of prostate cancer
| Project/Area Number |
26460417
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
小林 基弘 福井大学, 学術研究院医学系部門, 教授 (00362137)
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| Research Collaborator |
NAKAYAMA JUN 信州大学, 学術研究院医学系, 教授 (10221459)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | 前立腺癌 / 糖鎖 |
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| Outline of Final Research Achievements |
We examined the significance of α-dystroglycan (α-DG) glycosylation in perineural invasion (PNI) of human prostate carcinoma. In PNI region, we found that the expression level of α-DG glycosylation in carcinoma cells was different from that of non-PNI area. Although, either reduced or increased expression was observed in more than half of the cases, these changes were not associated with particular histological pattern of carcinoma, as assessed by Gleason grading. In addition, we also found that expression level of α-DG glycosylation in PNI correlated with that of non-PNI area only in higher Gleason grade group (>= Gleason pattern 4).
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| Free Research Field |
病理学
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