2016 Fiscal Year Final Research Report
Molecular and morphologic features of uterine adenocarcinoma
| Project/Area Number |
26460419
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Research Collaborator |
Wada Tomoko (篠崎 智子)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 子宮腺癌 / 子宮頸部通常型腺癌 / 子宮頸部胃型腺癌 / Human papillomavirus / p16 / p53 / HIK1083 |
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| Outline of Final Research Achievements |
WHO classification set up new entities of endocervical adenocarcinoma (ECA), namely the 'usual type' and 'gastric type.' Usual-type ECAs (U-ECAs) are virtually always associated with high-risk human papillomavirus (HR-HPV) infection. Gastric-type ECAs (G-ECAs) are believed not to be associated with HR-HPV infection. We noticed that some ECAs contain morphologically usual type-like and gastric type-like components in a single tumor; we have named these "G+U" ECAs. We analyzed 70 cases of endocervical adenocarcinoma. We identified 48 pure U-ECAs, nine pure G-ECAs and 13 G+U ECAs. Most G+U ECAs showed no HR-HPV infection and showed frequent HIK1083 expression and aberrant p53 expression. The other G+U ECAs showed HR-HPV infection and frequent p16+/p53-/HIK1083-; immunophenotype. Most of the G+U ECAs we examined were genuine HPV-unrelated G-ECAs with usual type-like components. A small population of G+U ECAs was genuine HPV-related U-ECAs with gastric type-like components.
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| Free Research Field |
婦人科病理
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