2016 Fiscal Year Final Research Report
Significance of Wnt-signal and hedgehog-signal pathways and GNS mutation in carcinogenesis of gastric adenocarcinoma of fundic gland type
| Project/Area Number |
26460428
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Juntendo University |
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Principal Investigator |
YAO Takashi 順天堂大学, 医学部, 教授 (20243933)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 胃底腺型胃癌 / GNAS / Hedgehogシグナル伝達系 / Wntシグナル伝達系 |
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| Outline of Final Research Achievements |
From the above results, it was re-confirmed that the GNAS gene mutation is involved in the carcinogenesis or progression of gastric fundus gland type gastric cancer, and it has been shown for the first time that KRAS and BRAF gene mutations are not related to gastric fundus gland type gastric cancer It was. It is suggested that suppression of Sonic hedgehog signal may be involved in the development or progression of gastric fundus gland type gastric cancer in addition to activation of Wnt / β-catenin signal (particularly methylation is involved in particular) and GNAS gene mutation It was done.
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| Free Research Field |
医学
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