2016 Fiscal Year Final Research Report
Analysis on the differences of tumorigenesis between MCPyV-positive and -negative Merkel cell carcinomas and its application to therapy
| Project/Area Number |
26460433
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Tottori University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | メルケル細胞癌 / ポリオーマウイルス / がん遺伝子 / 遺伝子変異 |
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| Outline of Final Research Achievements |
Different mechanism of carcinogenesis between MCPyV-positive and -negative Merkel cell carcinoma (MCC) is suggested because expressions of Akt/mTOR/4E-BP1 Pathway Signals or CADM1 and MAL were associated with MCPyV infection or prognosis, and immunoglobulin expression was observed only in MCPyV-positive MCC. MCPyV-DNA was frequently detected in Langerhans cell histiocytosis or Langerhans cell sarcoma.A new in situ hybridization and immunohistochemistry with a novel antibody to detect small T-antigen expressions ofMCPyV was developed.
Phylogeny of MCPyV genomes obtained from Japanese MCPyV-infected MCCs revealed that MCPyV strains in Japanese MCCs are distinct from Caucasian type MCPyVs.
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| Free Research Field |
病理学
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