The significance of CD169+ macrophages in patients with malignant tumors

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460454
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Kumamoto University
• Principal Investigator: OHNISHI Koji 熊本大学, 大学院生命科学研究部(医), 助教 (40613378)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: マクロファージ / リンパ節 / CD169 / 癌免疫

Outline of Final Research Achievements

As the expectation for cancer immunotherapy increases, the importance of cancer immunity monitoring is increasing. We focused on the importance of lymph node macrophages in cancer immunity and performed the following analysis. CD 169 expression of lymph node macrophages was analyzed in patients with melanoma, uterine body cancer, pancreatic cancer, breast cancer. As a result, it was revealed that cancer immunity mediated by CD8 positive T cells is elevated in cases with high CD 169 expression, and survival rate after surgery is good. In culture experiments, it was revealed that CD169 highly expressed macrophages highly express CCL8 and CXCL10 having lymphocyte activating action.

Free Research Field

病理学