2016 Fiscal Year Final Research Report
Epidemiological survey and immunological and molecular pathological study of hepatocellular adenoma in Japan
| Project/Area Number |
26460461
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TAKAYAMA Tadatoshi 日本大学, 医学部, 教授 (30280944)
KANEITA Yoshitaka 大分大学, 医学部, 教授 (40366571)
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| Research Collaborator |
IZU Asami
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 肝細胞腺腫 / WHO分類 / 疫学調査 / 病理診断 / 臨床病理学的研究 / 免疫組織化学的研究 / 分子病理学的研究 |
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| Outline of Final Research Achievements |
Hepatocellular adenoma (HCA) is hepatic benign neoplasm, which has been estimated to have a lower prevalence in Japan than in Western countries, though definitive data are as yet lacking. Importance of HCA research is increasing because that histological feature is difficult in differentiating between HCA and well differentiated hepatocellular carcinoma and one subtype of HCA has potentiality to malignant transformation. We endeavored to ascertain the HCA prevalence in Japan, in this study. We sent a questionnaire survey to hospitals, 402 in total, conducting large numbers of liver operations. The response rate was approximately 80%. In the replies, experience of HCA case was approximately 30%. Definitive HCA cases in surgically resected liver was 117, in which gender, age and clinical background was examined. Subtype was immunohsitochemically determined. In some cases, genetic abnormalities were investigated.
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| Free Research Field |
人体病理学、実験病理学
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