2016 Fiscal Year Final Research Report
Induction of cancer stem-like properties by adhesion with epithelial-like feeder cells
| Project/Area Number |
26460464
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
笠原 正典 北海道大学, 医学研究科, 教授 (30241318)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | HTLV-1 / ATL / がん幹細胞 / 膵癌 |
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| Outline of Final Research Achievements |
Adult T cell leukemia / lymphoma (ATL) is a very poor prognostic peripheral T cell lymphoma with very strong invasivasion into tissues and consequent drug resistance. We found that ATL cells acquire "cancer stem cell-like propeties such as cell cycle arrest and apoptosis resistance by adhesion with normal epithelial cells (Am J Pathol, 2013). We think that this phenomenon leads to understanding not only of ATL but also the mechanism of drug resistance acquisition in malignant tumor which caused tissue invasion. In this study, in order to raise the universality of this phenomenon focusing on pancreatic cancer of intractable solid cancer, the mechanism of the development of cancer stem cell-like cells induced by adhesion to epithelial-like feeder cells. Finally, we aimed to establish a novel therapeutic concept capable of responding to a wide range of refractory cancers targeting "prevention of cancer stem cell development" induced by adhesion with normal epithelium.
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| Free Research Field |
実験病理
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