2016 Fiscal Year Final Research Report
Regulation of heterogeneity of tumors from the viewpoint of cancer initiating cells
Project/Area Number |
26460470
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Experimental pathology
|
Research Institution | Osaka University |
Principal Investigator |
Morii Eiichi 大阪大学, 医学系研究科, 教授 (10283772)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Keywords | 腫瘍幹細胞 / 多様性 / 制御因子 |
Outline of Final Research Achievements |
Cancer initiating cells are resistant to anti-tumor therapies. In this study, we showed that ALDH-hi cells, which are considered as cancer initiating cells, are regulated by Nodal, and that ALDH-hi cells expressed S100A4 strongly. S100A4 is related to proliferation and invasion ability of uterine endometrial carcinoma, and S100A4-hi cases possessed "MELF" pattern. In addition, arginine synthetic enzyme was also upregulated in ALDH-hi cells. This enzyme epigenetically controlled mTOR-complex member, DEPTOR. These results suggested that cancer initiating cells are controlled by various factors, which are related to yield of heterogenous populations of tumors.
|
Free Research Field |
病理学
|