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2016 Fiscal Year Final Research Report

Identification of driver genes in inflammation-related intestinal tract carcinogenesis

Research Project

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Project/Area Number 26460472
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Experimental pathology
Research InstitutionTottori University

Principal Investigator

Okada Futoshi  鳥取大学, 医学部, 教授 (00250423)

Project Period (FY) 2014-04-01 – 2017-03-31
Keywords炎症発癌 / 慢性炎症 / ドライバー遺伝子
Outline of Final Research Achievements

I tried to determine driver genes in inflammation-related intestinal tract carcinogenesis by using three-dimentional tissue culture system. Solid surface foreign-body such as plastic plate was used to induce inflammation. Reconstitive intestinal tract obtained from K-ras mutant mice formed dormant tumors under chronic inflammation in mice. Intestinal tissue obtained from p53-/- mice developed lethal tumors under chronic inflammation; however, the tissue spontaneously regressed under acute inflammation. Moreover, intestinal tissue obtained from p53+/- mice does not form tumors in the chronic inflammatory environment. I found that p53 gene mutation has a role in the development of inflammation-related intestinal carcinogenesis.

Free Research Field

実験病理学

URL: 

Published: 2018-03-22  

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