Search for therapeutic targets for small cell lung cancer using a new orthotopic transplantation model.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460481
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Microbial Chemistry Research Foundation
• Principal Investigator: SAKAMOTO Shuichi 公益財団法人微生物化学研究会, 微生物化学研究所 沼津支所, 主任研究員 (60346070)
• Co-Investigator(Renkei-kenkyūsha): INOUE Hiroyuki 公益財団法人微生物化学研究会, 微生物化学研究所動物施設, 研究員 (50601548)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 小細胞肺癌 / 癌転移 / 自然転移モデル / 治療標的

Outline of Final Research Achievements

Small cell lung cancer (SCLC) accounts for nearly 20% of lung cancer cases and one of the most aggressive cancers with highly metastatic ability. In this study, we assessed anti-tumor activities of compounds and an antibody and searched the metastatic genes using our originally developed orthotopic metastasis model of SCLC. Our results are listed below.(1) Our model has the same aspects of SCLC patients and is useful for assessment of anti-tumor activities of drug seeds.(2) We identified a membranous protein as a good candidate for anti-tumor antibody-drug target. (3) We established a protocol for identification of genes differentially expressed between orthotopic tumors and metastatic tumors.

Free Research Field

腫瘍生物学