2016 Fiscal Year Final Research Report
Histone adaptation of cancer cell
| Project/Area Number |
26460482
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | National Cancer Center Japan |
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Principal Investigator |
Fujii Satoshi 国立研究開発法人国立がん研究センター, 先端医療開発センター, ユニット長 (30314743)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | Cancer / Histone |
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| Outline of Final Research Achievements |
A tumor suppressor gene was regulated by cooperation of histone H3 variant incorporated by histone chaperone and histone modification working together with incorporation of histone H3 variant. On the other hand, incorporation of histone H3 variant did not lead to complete change of gene expression profiling distinguishing two different breast cancer subtypes.
Significant correlations between CAF (cancer associated with fibroblast)-TEM1-positivity or CAF-TEM1-intensity and RFS (recurrence-free survival), OS (overall survival), or COS (cancer-related overall survival) were observed (P < 0.001, Kaplan-Meier curves) regarding gastric cancer patients.
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| Free Research Field |
実験病理学
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