2016 Fiscal Year Final Research Report
Analysis of osteoclastogenesis by intra- and extra-medullary regulation to prevent osteoporosis
| Project/Area Number |
26460488
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Tottori University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 炎症 / 破骨細胞 / 骨髄細胞 / 腹腔細胞 / 自然リンパ球 / 骨吸収 / 免疫学 |
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| Outline of Final Research Achievements |
To prevent post-menopausal osteoporosis, persistent and reliable therapy is required. For this purpose, I am studying the regulation mechanisms of development of osteoclasts which resorb bone. I detected the osteoclastogenesis in both male and female mice is controlled by intra- and extra-medullary regulation. Cells for latter regulation are present in peritoneal cavities, and once lost, are not to be recovered. The flow cytometric analysis of bone marrow T cells did not show any significant difference with or without hypotonic treatment for removing peritoneal cells; however, the response to peritoneal cells is dependent on bone marrow T cells. The phenotype in these treated mice resembles the ovariectomized one carrying osteoporosis, suggesting the presence of common pathway in both conditions. The decision of the regulatory cells in the peritoneal cavity will result in the development of novel therapy for osteoporosis.
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| Free Research Field |
医歯薬学
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