2016 Fiscal Year Final Research Report
Study of the mechanism of resumption of development of Strongyloides larvae by perception of host environment
| Project/Area Number |
26460509
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Parasitology (including sanitary zoology)
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 糞線虫 / 感染幼虫 / GFAT / 発現調節 |
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| Outline of Final Research Achievements |
It was not well understood what kind of environmental cues are perceived by Strongyloides infectious larvae (L3i), which leads to changes in gene expression and morphology. In the present study, we especially focused on studying mechanism of regulation of expression of GFAT1 gene, that was identified as one of the genes which showed remarkably up-regulated expression, once larvae are inside the animal host.
Taken the experimental results obtained in the present study together, we concluded that glucose concentration surrounding larvae are the most responsible for the elevation of GFAT1 expression. It was presumed that the elevation of GFAT1 expression is under the control of neurological pathway which involves muscarinic receptors.
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| Free Research Field |
寄生虫学
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