Elucidation of the invasive infection mechanism of the opportunistic infectious fungus Candida globrata

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460519
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Bacteriology (including mycology)
• Research Institution: Chiba University
• Principal Investigator: CHIBANA HIROJI 千葉大学, 真菌医学研究センター, 准教授 (30333488)
• Research Collaborator: KURATA Shoichiro 東北大学, 大学院薬学研究院, 教授 ; TAKAHASHI Azusa 千葉大学, 真菌医学研究センター, 技術職員 ; SATO Michiyo 千葉大学, 真菌医学研究センター, 特任助教
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 病原真菌 / 病原因子 / 薬剤標的

Outline of Final Research Achievements

We have screened strains by which greatly reduced a virulence to the Drosophila from the comprehensive gene knockout library of the Candida glabrata, on the collaboration with Tohoku University Kurata's laboratory. After foucused on the 10 strains from that, and pushing forward the infection experiments with the silkworm larva, We identified A and B gene defective strains respectively in which virulence particularly decreased. The protein which encoded by gene A was located on the cell membrane, and it was a factor necessary to maintain the cell membrane, and it was suggested to be a gene necessary to assimilate serum ingredient. We settle those results, and we are preparing publishing a papar. About the B gene, we are going to analyze a relation with the pathogenicity.

Free Research Field

医真菌学