Membrane trafficking regulating LPS-induced autophagy

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460522
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Bacteriology (including mycology)
• Research Institution: 公益財団法人結核予防会 結核研究所 (2015-2016); Hamamatsu University School of Medicine (2014)
• Principal Investigator: Seto Shintaro 公益財団法人結核予防会 結核研究所, 生体防御部 免疫科, 研究員(移行) (50383203)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: オートファジー / LPS / Rab GTPase

Outline of Final Research Achievements

We screened Rab GTPase for regulators of LPS-induced autophagy. We have already identified that Rab39a binds to Beclin-1, PI3 kinase regulator and negatively regulates LPS-induce autophagy In this study, we found that Rab26 binds to Beclin-1 by immunoprecipitation analysis. Fluorescence microscopy analysis revealed that Rab26 localizes to lysosomes. Knock-down analysis showed that Rab26 negatively LPS-induced autophagy.

Free Research Field

感染免疫