2017 Fiscal Year Final Research Report
Regulation of bacterial pathogenicity by the ABC transporter
| Project/Area Number |
26460524
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bacteriology (including mycology)
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2018-03-31
|
| Keywords | 細菌 / 多剤耐性 / 病原性 / トランスポーター / 異物排出 / 薬剤排出 / サルモネラ / MacAB |
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| Outline of Final Research Achievements |
Xenobiotic transporter contributes to bacterial multidrug resistance by expelling antibacterial drugs. However, physiological roles of most of these transporters remain unknown. In this study, we focused on the ABC type transporter MacAB, and conducted physiological function analysis. There were findings that transporters were related with the bacterial attachment to the host cell surface, involved in resistance to oxidative stress, involved in maintenance of biofilm formation, and partly in bacterial survival in the intestine. In addition, inhibitor candidates of transporters were selected by the screening. In the situation where the physiological functions of many transporters are unknown, these results clarify their physiological functions and these are important information useful for the development of new drugs.
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| Free Research Field |
細胞生物学、細菌学
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