Analyses of the functions of Bordetella BopC that induce actin-dependent necrotic cell death.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460535
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Bacteriology (including mycology)
• Research Institution: Kitasato University
• Principal Investigator: Kuwae Asaomi 北里大学, 感染制御科学府, 准教授 (60337996)
• Co-Investigator(Renkei-kenkyūsha): ABE Akio 北里大学, 大学院感染制御科学府, 教授 (50184205)
• Research Collaborator: MOMOSE Fumitaka 北里大学, 大学院感染制御科学府, 講師
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 百日咳 / III型分泌機構 / エフェクター

Outline of Final Research Achievements

Whooping cough is largely known as a vaccine preventable disease. However, there are many examples that children who were vaccinated have typical symptoms of whooping cough, meaning Bordetella pertussis, which is a causative agent of whooping cough, is obtaining resistance against the vaccine. It is also largely unknown the molecular mechanisms how B. pertussis cause the severe coughing. In the present study, we investigated the function of BopC, which is one of the virulence factors produced by Bordetella, during the bacterial infection. Our results suggest that BopC induce cell death against mammalian cells in the actin polymerization-dependent manner.

Free Research Field

医科細菌学