2016 Fiscal Year Final Research Report
Mechanism of Fas-mediated inflammatory response against bacterial infection in vivo
| Project/Area Number |
26460539
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bacteriology (including mycology)
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TSUTSUI Hiroko 兵庫医科大学, 医学部, 主任教授 (40236914)
YONEHARA Shin 京都大学, 大学院・生命科学研究科, 教授 (00124503)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | Fasシグナル / 炎症性サイトカイン / 細菌感染 |
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| Outline of Final Research Achievements |
Fas signaling pathway is known to play a pivotal role in apoptosis induction. In addition, we have revealed that macrophages produced IL-1b by Fas-mediated inflammation in bacterial infection. However, the precise role of Fas-mediated cytokine production in actual pathogen infection was unclear. In this study, we found that Fas-mediated IL-1b contributes to the induction of novel helper T cells which produce IFN-g/IL-17 (called Th17/Th1 cells). This study provides a deeper understanding of the molecular mechanisms of Th17/Th1 induction during pathogenic microbe infection in vivo.
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| Free Research Field |
細菌学・感染免疫学
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