2016 Fiscal Year Final Research Report
Herpesvirus switching mechanism of gene regulation.
| Project/Area Number |
26460558
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | University of the Ryukyus (2016)
Kyushu University (2014-2015) |
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Principal Investigator |
Ohno Shinji 琉球大学, 医学(系)研究科(研究院), 教授 (50419529)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | ヘルペスウイルス / ガンマヘルペスウイルス / 後期遺伝子 / 遺伝子発現 |
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| Outline of Final Research Achievements |
We analyzed the viral gene regulation of gammaherpesvirus. The open reading frame (ORF) 35 protein was considered to be essential for the viral growth. However, we revealed that the protein was not essential, but plays an important role for the efficiency of the viral replication. In addition, ORF35 protein was necessary for reactivation from latent infection.
We also analyzed the function of ORF31 protein. And the protein was revealed to regulate viral gene expression and we identified functional domain of ORF31. Host proteins which bind to ORF31 and regulate viral replication was searched, and we found candidates. We are currently studying about these proteins.
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| Free Research Field |
ウイルス学
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