Inhibition of HIV-1 by Gag peptides

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460566
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Virology
• Research Institution: National Institute of Infectious Diseases
• Principal Investigator: Murakami Tsutomu 国立感染症研究所, エイズ研究センター, 室長 (50336385)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: HIV-1 / ペプチド / Gag蛋白質 / 抗HIV-1薬

Outline of Final Research Achievements

We have constructed peptide libraries for matrix (MA) and capsid (CA) proteins of HIV-1 and investigated whether introduction of these peptides could inhibit HIV-1 replication in cell culture. We found that 9th fragment of the MA proteins, several fragments of the CA proteins including 15th fragment which contains the linker region of N- and C-terminal domains of CA and 19th fragment which contains the dimmer interface of C-terminal domain of CA have modest anti-HIV-1 activities in vitro, suggesting that these peptides could be lead compounds for further modifications.

Free Research Field

ウイルス学