Signaling mechanisms of chronic inflammation and metabolic diseases

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460571
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Immunology
• Research Institution: Mie University
• Principal Investigator: OGATA Masato 三重大学, 医学系研究科, 教授 (60224094)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 慢性炎症 / MAPキナーゼ / マクロファージ / 代謝症候群 / p38

Outline of Final Research Achievements

Chronic inflammation and glucose tolerance in high fat diet-induced obesity and NASH model mice were ameliorated in mutant mice in which p38alpha gene was disrupted in hematopoietic cells. As a possible mechanism, involvement of p38alpha in the chemotaxis of proinflammatory M1 macropahges to their target organs was suggested. The p38alpha signaling cascade might be a common therapeutic target of diseases related to chronic inflammation induced by obesity and fatty liver.

Free Research Field

免疫学