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2016 Fiscal Year Final Research Report

Investigation of the molecular mechanisms to control T-cell exhaustion

Research Project

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Project/Area Number 26460579
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Immunology
Research InstitutionEhime University

Principal Investigator

Yamada Takeshi  愛媛大学, 医学系研究科, 准教授 (40333554)

Project Period (FY) 2014-04-01 – 2017-03-31
KeywordsT細胞疲弊 / CD8 / 慢性型感染症
Outline of Final Research Achievements

It has been known that T-cell exhaustion reduces function of T cells to eliminate pathogens during chronic infections such as HIV infection. In this study, we thus analyzed the inducible mechanisms of T-cell exhaustion using a mouse model. Our study revealed that T-cell exhaustion was induced in antigen-specific CD8 T cells lacking a tumor suppressor Menin after infection with an intracellular pathogen Listeria. We observed that Menin deficiency enhanced terminal-effector differentiation and increased expression of inhibitory receptors in activated CD8 T cells, suggesting that Menin controls differentiation into effectors and inhibits T-cell exhaustion.

Free Research Field

感染免疫

URL: 

Published: 2018-03-22  

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