2016 Fiscal Year Final Research Report
A basic research of p73 activation as a novel treatment for p53-mutant type cancer
Project/Area Number |
26460624
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Applied pharmacology
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Research Institution | University of Tsukuba |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Keywords | p73 / がん |
Outline of Final Research Achievements |
p73 has a high homology to tumor-suppressor gene p53, and acts as a translational factor like p53 in p53-mutant type cancer cells. In this study, we evaluated the tumor growth inhibition of p73 in human tumor cell lines. p73 was induced by 5-FU or irinotecan administration in the colon cancer cells (DLD-1, HCT116). Using HCT116, the function of p73 was investigated with various inhibition of related-molecules under 5-FU exposure. As the results, p73 tumor-suppressive function was little in this cancer line regardless of harboring p53 mutation. Further studies are needed to develop a novel strategy using p73 for anticancer treatments.
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Free Research Field |
消化器内科学
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