2016 Fiscal Year Final Research Report
Safety of drugs inducing megalin in renal tubles using cadmium
| Project/Area Number |
26460631
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Osaka University of Pharmaceutical Sciences (2016)
Jichi Medical University (2014-2015) |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 腎臓 / 尿細管 / カドミウム / エンドサイトーシス / 薬物有害反応 / 毒性 |
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| Outline of Final Research Achievements |
In this study, we found that the mRNA expressions of endocytic receptors in cultured cells, which are involved in reabsorption of cadmium in renal tubular cells, significantly increased and accompanied with increase in concentration of cadmium, resulting in cytotoxicity with exposure to several drugs.
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| Free Research Field |
医療薬学
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