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2016 Fiscal Year Final Research Report

Pharmaceutical studies for the elucidation and prevention of molecule-targeting therapeutic agents-induced acne-like rash in cancer patients

Research Project

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Project/Area Number 26460633
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied pharmacology
Research InstitutionTokyo University of Pharmacy and Life Science

Principal Investigator

Sato Takashi  東京薬科大学, 薬学部, 教授 (90266891)

Co-Investigator(Renkei-kenkyūsha) AKIMOTO Noriko  東京薬科大学, 薬学部, 助教 (80297605)
Project Period (FY) 2014-04-01 – 2017-03-31
Keywordsざ瘡様皮疹 / ゲフィチニブ / 皮脂腺 / 皮脂 / 脂腺細胞 / 抗がん薬
Outline of Final Research Achievements

A treatment of EGF receptor tyrosine kinase inhibitors (EGFR-TKIs) such as gefitinib and erlotinib has been reported to frequently exhibit a typical side effect, acne-like rash, in cancer patients. However, there is little evidence in molecular mechanisms of acne-like rash as well as the therapeutic and preventive strategies against the side effect in the skin. In the present study, we have provided novel evidence that 1) EGFR-TKIs are excreted to sebaceous units in the skin of humans, 2) human sebaceous progenitor cells are prepared, 3) EGFR-TKIs augment the sebum production, and 4) pharmacological candidates to suppress the sebum production are found from natural products. These findings are likely to make contributions to the promotion of proper use of EGFR-TKIs as well as other anti-tumorigenic agents and to the appearance care of cancer patients.

Free Research Field

生化学、皮膚科学、細胞生物学

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Published: 2018-03-22  

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