2016 Fiscal Year Final Research Report
Modifications of hippocampal dysfunction in diabetic mice by chronic kidney failure: Involvement of endoplasmic reticulum stress
| Project/Area Number |
26460634
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 小胞体ストレス / 海馬 / 脂質過酸化物 / 慢性腎不全 / シャペロンタンパク質 / Blood Urea Nitrogen / Creatinine |
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| Outline of Final Research Achievements |
Recent studies have demonstrated that Chronic kidney disease (CKD) contributes to cognitive dysfunction. The hippocampus has been shown to play a critical role in the formation of new memories. The present study investigated the expression of stress-associated proteins in the hippocampus of CKD mice. The levels of 4-hydroxynonenal-adducted proteins, the makers of lipid peroxidation, in the hippocampus of CKD mice were significantly increased at 8 weeks after 5/6 nephrectomy. Moreover, an increase of 78-kDa glucose-regulated protein, an indicator of Endoplasmic Reticulum (ER) stress, was detected in the hippocampus. These results suggest that not only oxidative stress but also ER stress contributes to cognitive dysfunction in CKD mice.
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| Free Research Field |
神経化学・薬理学
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