2016 Fiscal Year Final Research Report
Development of lipoprotein lipase assays targeted to remnant lipoproteins in cardiovascular diseases.
| Project/Area Number |
26460640
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Kagawa Nutrition University (2016)
Gunma University (2014-2015) |
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Principal Investigator |
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| Research Collaborator |
Okajima Fumikazu 群馬大学, 生体調節研究所, 教授 (30142748)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | リポ蛋白リパーゼ（LPL) / レムナントリポ蛋白 / 脂肪負荷 / 中性脂肪 / 肝性リパーゼ（HTGL) |
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| Outline of Final Research Achievements |
Plasma TG levels are known to increase after food intake. Also it has been believed that plasma LPL levels increase associated with the increase of plasma TG. However, we found that LPL levels don't change after fat load and sugar intake in non-heparin plasma.We also found that most of the increased TG after food intake was found in remnant lipoprotein fraction as RLP-TG.RLP-TG increased greatest in 4-6 h after food intake which was associated with the LPL concentration in remnant lipoproteins (LPL/RLP-TG interaction) .
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| Free Research Field |
臨床検査
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