High-density lipoprotein HDL and apolipoprotein M as the glucose metabolism marker

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460641
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Gunma University
• Principal Investigator: Kimura Takao 群馬大学, 大学院医学系研究科, 講師 (90396656)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 経口血糖負荷試験 / 動脈硬化症 / 糖代謝 / 高密度リポ蛋白 / アポリポ蛋白

Outline of Final Research Achievements

We assessed the oral glucose tolerance test (OGTT) and lipid metabolism among young and middle aged Japanese subjects. We also measured the serum concentration of apolipoprotein M (ApoM) using ELISA. Serum ApoM concentrations were positively correlated with total cholesterol (TC) and high-density lipoprotein cholesterol (HDL-C). Serum ApoM concentrations were positively correlated with Matsuda Index which represents both hepatic and peripheral tissue sensitivity to insulin. Matsuda Index is simple to calculate and provides a reasonable approximation of whole-body insulin sensitivity from the OGTT. OGTT needs four times of drawing blood. Therefore to calculate Matsuda Index needs four times of drawing blood. The positive correlation between serum ApoM concentration and Matsuda Index indicates that serum ApoM concentration might reflect whole-body insulin sensitivity. In summary, whole-body insulin sensitivity might be assessed by measurement of serum ApoM concentration.

Free Research Field

代謝学（動脈硬化）