Anti- and pro-atherosclerotic features of high-density lipoprotein

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460642
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: TOZUKA MINORU 東京医科歯科大学, 大学院保健衛生学研究科, 教授 (60431954)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: HDL / 酸化LDL / コレステロール引き抜き能 / 抗酸化作用 / 抗炎症作用 / apolipoprotein A-I / myeloperoxidase / paraoxonase 1

Outline of Final Research Achievements

It is believed that the estimation of the functions of high-density lipoprotein (HDL), anti-atherosclerotic lipoprotein, is essential for medical treatment and prevention of cardiovascular disease. In the present study, we clarified a part of the mechanism of anti-atherosclerotic functions, such as cholesterol efflux capacity, anti-inflammation, and antioxidant ability, induced by HDL. In addition, we indicated that the result of cholesterol efflux capacity given an opposite interpretation was occasionally obtained by using slightly different conditions in the assay procedure accepted widely. These observations could be important to standardize the assay methods for the estimation of the functions of HDL.

Free Research Field

臨床化学、リポタンパク代謝