2016 Fiscal Year Final Research Report
Investigation of new vasoactive peptides as risk/biomarker for coronary atherosclerosis
| Project/Area Number |
26460659
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 動脈硬化 / 冠動脈疾患 / ペプチド / バイオマーカー / 創薬 |
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| Outline of Final Research Achievements |
The present study (cellular, animal, and clinical research) provides the first evidence to demonstrate that new vasoactive peptides regulate atherosclerosis. The atherosclerosis is stimulated by cardiotrophin-1, fetuin-A, kisspeptin-10, and stanniocalcin (STC)-2-derived segments, but is suppressed by STC-1, omentin-1, tumor necrosis factor-stimulated gene-6 (TSG-6), and urocortin-1. This study also shows that plasma levels of kisspeptin-10, omentin-1, and TSG-6 may become candidates for biomarker of coronary atherosclerosis in patients with ischemic heart disease. Further studies are needed to make anti-atherosclerotic drugs on the basis of the good peptides, such as omentin-1, and TSG-6, and urocortin-1.
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| Free Research Field |
循環器内科
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