Tests for self-renewal signals of acute leukemia stem cells and prediction of the effects of molecular-targeted drugs for the signals

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460669
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: TOHDA Shuji 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (80251510)
• Research Collaborator: OHTAKA Mika 東京医科歯科大学, 大学院医歯学総合研究科 ; SHIRATORI Erika 東京医科歯科大学, 大学院医歯学総合研究科
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 白血病 / 白血病幹細胞 / 分子標的薬 / 薬剤感受性検査

Outline of Final Research Achievements

To cure acute leukemia, development of two tests is required: tests to identify the signals regulating stemness of leukemia stem cells and sensitivity tests of the molecular-targeted drugs for the signals. We have found that BMI1 signal and NOTCH signal regulate the stemness of leukemia stem cells using in vitro culture assay. We also showed that the inhibitors suppressed the cell growth and stemness-related signaling. These findings indicate the possibility that the inhibitors can be molecular-targeted drugs. We also developed the drug-sensitivity tests.

Free Research Field

医歯薬学