2016 Fiscal Year Final Research Report
Analysis of the immune response of platelet activation and macrophages by H. pylori membrane proteins
| Project/Area Number |
26460680
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Kochi University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | Helicobacter pylori / 免疫性血小板減少症 / H, pylori 膜蛋白 |
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| Outline of Final Research Achievements |
Helicobacter pylori infection has been assocoated in the pathogenesis of immune thrombocytopenic purpura (ITP). We reported the possibility that the immunocomplexes consisting of H. pylori outer membrane (Hp-OMP) , platelet and anti Hp-OMP antibodies were involved in development of H.pylori associated ITP as an extra mechanism.Patients with ITP were classified into 3 groups: H. pylori - negative (Hp-N); H. pylori - positive and completely or partially responsive to treatment (CR); H. pylori - positive and irresponsive to treatment (NR). Reactivity of antibodies to Hp-OMP was examined by ELISA. Value of anti-Hp-OMP antibody by ELISA, Hp-OMP was significant higher in infected groups (CR and NR) than that in Hp-N. Its value was higher in CR than that in NR. Phagocytosis of the immunocomplexes were not detected by microscopic and immunoblot analysis.
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| Free Research Field |
感染症学
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