2017 Fiscal Year Final Research Report
Induction and Enhancement of Iodide Transporter Expression in Gastric Cancer Cells
| Project/Area Number |
26460684
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
菱沼 昭 獨協医科大学, 医学部, 教授 (40201727)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | ヨードトランスポーター / レチノイド / 胃癌 |
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| Outline of Final Research Achievements |
The iodide transporter, NIS, is abundantly expressed in thyroid, as well as breast cancer and gastric cancer. Tumor-specific enhancement of its expression would make it possible to apply radio-iodide to target the tumors. We found significant induction of NIS expression by RXR agonists, and its enhancement by AKT inhibitors, in an in vitro model of gastric cancer. A number of translation inhibitors also induced the NIS expression in several cancer cell lines. Comprehensive analysis of miRNA expression in those cells suggested some miRNAs as potential NIS stimulators.
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| Free Research Field |
内分泌学
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