2017 Fiscal Year Final Research Report
Role of PU.1 suppressive target gene, metallothionein, as a forecasting biomarker for anticancer agents
Project/Area Number |
26460685
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Laboratory medicine
|
Research Institution | Tohoku Medical and Pharmaceutical University (2016-2017) Kitasato University (2014-2015) |
Principal Investigator |
|
Project Period (FY) |
2014-04-01 – 2018-03-31
|
Keywords | メタロチオネイン / 抗がん剤 / 効果予測マーカー |
Outline of Final Research Achievements |
We previously identified a multifunctional factor, metallothionein (MT), as a myeloid master transcription factor PU.1 suppressive target gene. We previously revealed that MT strongly suppresses all-trans retinoid acid induced acute promyelocytic leukemia (NB4) cells differentiation. In this study, we revealed that MT not only inhibits myeloid cell differentiation, but also bears activity for drug resistance, especially for cytarabine (Ara-C). We revealed that the MT over-expressed NB4 cells bears 1.5 to 2.0 times higher ED50 doses of Ara-C compared to their controls.
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Free Research Field |
臨床検査医学
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